SOMATOSENSORY SYSTEMSDeep brain stimulation for chronic pain investigated with magnetoencephalographyKringelbach, Morten L.a; Jenkinson, Neda c; Green, Alexander L.a b; Owen, Sarah L.F.a; Hansen, Peter C.a; Cornelissen, Piers L.d; Holliday, Ian E.e; Stein, Johna; Aziz, Tipu Z.a b cAuthor Information aDepartment of Physiology, Anatomy and Genetics, University of Oxford bDepartment of Neurosurgery, Radcliffe Infirmary cNuffield Department of Surgery, John Radcliffe Hospital, Oxford dDepartment of Psychology, Newcastle University, Newcastle eNRI, Aston University, Birmingham, UK Correspondence and request for reprints to Dr Morten L. Kringelbach, and Professor Tipu Aziz, Department of Physiology, Anatomy and Genetics, Sherrington Building, Parks Road, Oxford OX1 3PT, UK Tel: +44 1865282271; fax: +44 1865272469; e-mails: email@example.com, firstname.lastname@example.org Sponsorship: The authors were funded by the Wellcome Trust, the Medical Research Council, the Templeton Foundation, the Norman Collisson Foundation and the Charles Wolfson Charitable Trust. Received 11 September 2006; accepted 14 September 2006 NeuroReport: February 12th, 2007 - Volume 18 - Issue 3 - p 223-228 doi: 10.1097/WNR.0b013e328010dc3d Buy SDC Metrics Abstract Deep brain stimulation has shown remarkable potential in alleviating otherwise treatment-resistant chronic pain, but little is currently known about the underlying neural mechanisms. Here for the first time, we used noninvasive neuroimaging by magnetoencephalography to map changes in neural activity induced by deep brain stimulation in a patient with severe phantom limb pain. When the stimulator was turned off, the patient reported significant increases in subjective pain. Corresponding significant changes in neural activity were found in a network including the mid-anterior orbitofrontal and subgenual cingulate cortices; these areas are known to be involved in pain relief. Hence, they could potentially serve as future surgical targets to relieve chronic pain. © 2007 Lippincott Williams & Wilkins, Inc.