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Cortical activation during memory-guided saccades

Özyurt, Jalea; Rutschmann, Roland M.b; Greenlee, Mark W.b

doi: 10.1097/01.wnr.0000224765.00078.4e

Using functional magnetic resonance imaging, we compared responses during visually guided saccades with those evoked during memory-guided saccades, in which participants executed saccades to remembered locations. Eye movements were recorded in the magnetic resonance tomograph. Significantly stronger activation during memory-guided saccades was observed in the posterior portion of the right inferior frontal gyrus, in the left inferior frontal eye field, in the posterior parietal cortex, as well as in the right posterior superior temporal gyrus. The posterior part of the dorsal anterior cingulum and a small voxel cluster in the dorsolateral prefrontal area, anterior to the left inferior frontal eye field, were only active in the memory-guided condition.

aCognitive Neuroscience, Department of Psychology, Carl von Ossietzky University Oldenburg, Oldenburg

bInstitute for Experimental Psychology, University of Regensburg, Regensburg, Germany

Correspondence and requests for reprints to Professor Mark W. Greenlee, Institute for Experimental Psychology, University of Regensburg, Universitätsstrasse 31, 94100 Regensburg, Germany

Tel: +49 941 9433281; fax: +49 941 9433233; e-mail:

Sponsorship: This work was funded by the German Research Foundation (DFG, SFB 517, C9).

Received 23 February 2006; accepted 24 April 2006

© 2006 Lippincott Williams & Wilkins, Inc.