SOMATOSENSORY SYSTEMS, PAINDeep brain stimulation can regulate arterial blood pressure in awake humansGreen, Alexander L.a *; Wang, Shouyanb; Owen, Sarah L.F.b; Xie, Kangningb; Liu, Xuguanga; Paterson, David J.b *; Stein, John F.b; Bain, Peter G.c; Aziz, Tipu Z.a b Author Information aDepartment of Neurosurgery, Radcliffe Infirmary bUniversity Laboratory of Physiology, University of Oxford, Oxford cDivision of Neurosciences and Mental Health, Imperial College London, London, UK. Correspondence and requests for reprints to Dr A.L. Green, Department of Neurosurgery, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK Tel: +44 1865 224221/311188; fax: +44 1865 224786; e-mail: [email protected] Received 23 August 2005; accepted 25 August 2005 Sponsorship: Professor Aziz is supported by the Medical Research Council, UK. Sarah Owen and Shouyan Wang are supported by the Norman Collison Foundation. *Conflict of interest: A.L. Green, D.J. Paterson, J.F. Stein and T.Z. Aziz have applied for a US patent – Method and Apparatus for Regulating Blood Pressure. NeuroReport 16(16):p 1741-1745, November 7, 2005. | DOI: 10.1097/01.wnr.0000183904.15773.47 Buy Metrics Abstract The periaqueductal grey matter is known to play a role in cardiovascular control in animals. Cardiovascular responses to electrical stimulation of the periventricular/periaqueductal grey matter were measured in 15 awake human study participants following implantation of deep brain stimulating electrodes for treatment of chronic pain. We found that stimulation of the ventral periventricular/periaqueductal grey matter caused a mean reduction in systolic blood pressure of 14.2±3.6 mmHg in seven patients and stimulation of the dorsal periventricular/periaqueductal grey matter caused a mean increase of 16.7±5.9 mmHg in six patients. A comparison between ventral and dorsal electrodes demonstrated significant differences (P<0.05). These changes were accompanied by analogous changes in diastolic blood pressure, pulse pressure, maximum dP / dt but not in the time interval between each R wave on the electrocardiogram. © 2005 Lippincott Williams & Wilkins, Inc.