BRAIN IMAGINGSex differences in functional activation patterns revealed by increased emotion processing demandsHall, Geoffrey B. C.1 CA; Witelson, Sandra F.1 3; Szechtman, Henry1 2; Nahmias, Claude1Author Information 1The Brain-Body Institute, St. Joseph's Healthcare Hamilton, McMaster University, 314 Martha Wing, St.Joseph's Healthcare Hamilton, 50 Charlton Ave E., Hamilton, Ontario L8N 4A6 2Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario 3Department of Psychiatry and Behavioural Neurosciences, Albert Einstein/Irving Zucker Chair in Neuroscience, HSC-3G53 McMaster University, Faculty of Health Sciences, 1200 Main Street West, Hamilton, Ontario L8N 3Z5 CACorresponding Author: [email protected] Received 20 August 2003; accepted 9 September 2003 NeuroReport: February 9th, 2004 - Volume 15 - Issue 2 - p 219-223 Buy SDC Abstract Two [O15] PET studies assessed sex differences regional brain activation in the recognition of emotional stimuli. Study I revealed that the recognition of emotion in visual faces resulted in bilateral frontal activation in women, and unilateral right-sided activation in men. In study II, the complexity of the emotional face task was increased through tje addition of associated auditory emotional stimuli. Men again showed unilateral frontal activation, in this case to the left; whereas women did not show bilateral frontal activation, but showed greater limbic activity. These results suggest that when processing broader cross-modal emotional stimuli, men engage more in associative cofnitive strategies while women draw more on primary emotional references. © 2004 Lippincott Williams & Wilkins, Inc.