COGNITIVE NEUROSCIENCE AND NEUROPSYCHOLOGYThe anatomy of neglect without hemianopia: a key role for parietal–frontal disconnection?Doricchi, Fabrizio1 2 CA; Tomaiuolo, Francesco1 CA Author Information 1Fondazione Santa Lucia, via Ardeatina 306, 00179 Roma 2Dipartimento di Psicologia 39, Facoltà di Psicologia 1, Università degli Studi di Roma La Sapienza, Via dei Marsi 78, 00185 Roma, Italy CA,1Corresponding Authors: [email protected][email protected] Received 22 May 2003; accepted 23 June 2003 NeuroReport: December 2, 2003 - Volume 14 - Issue 17 - p 2239-2243 Buy Abstract We investigated the anatomical correlates of chronic unilateral neglect in right brain damaged patients with no visual field defects. Independently from basal ganglia or thalamus involvement, neglect patients had a subcortical area of maximal lesion overlap (maxov) in the superior longitudinal fasciculus (SLF). Neglect patients without lesion of subcortical nuclei had an additional maxov area in the rostralmost limit of the supramarginal gyrus (SmG). Patients without neglect showed a maxov area in the corticospinal tract with no involvement of the SLF or SmG. These findings call attention to the role of parietal–frontal disconnection in the pathogenesis of neglect. This disconnection can make neglect generalised and enduring also in patients suffering only partial damage of the parietal–temporal cortex, and who would otherwise show more selective attentional impairments. © 2003 Lippincott Williams & Wilkins, Inc.