Brain ImagingProton magnetic resonance spectroscopy of basal ganglia in chronic fatigue syndromeChaudhuri, A.CA; Condon, B. R.1; Gow, J. W.; Brennan, D.1; Hadley, D. M.2Author Information Departments of Neurology 1Clinical Physics 2Neuroradiology, Institute of Neurological Sciences, University of Glasgow, South Glasgow University Hospitals NHS Trust, Glasgow G51 4TF, UK CACorresponding Author: [email protected] Received 23 September 2002; accepted 16 December 2002 NeuroReport: February 10, 2003 - Volume 14 - Issue 2 - p 225-228 Buy Abstract Fatigue is a common symptom of neurological diseases that affect basal ganglia function. We used proton magnetic resonance spectroscopy (1H MRS) to study the metabolic functions of the basal ganglia in chronic fatigue syndrome (CFS) to test the hypothesis that fatigue in CFS may have a neurogenic component. 1H MRS of left basal ganglia was carried out in eight non-psychiatric patients with CFS and their results were compared to age- and sex-matched healthy asymptomatic healthy controls. A highly significant increase in the spectra from choline-containing compounds was seen in the CFS patient group (p < 0.001). In the absence of regional structural or inflammatory pathology, increased choline resonance in CFS may be an indicator of higher cell membrane turnover due to gliosis or altered intramembrane signalling. © 2003 Lippincott Williams & Wilkins, Inc.