Cognitive Neuroscience and NeuropsychologyAttention-related modulation of activity in primary and secondary auditory cortexGrady, Cheryl L.2,5; Van Meter, John W.1; Maisog, Jose Ma.3; Pietrini, Pietro1; Krasuski, Jack1; Rauschecker, Josef P.4Author Information 1Laboratory of Neurosciences, National Institute on Aging, Bethesda, MD, USA 3Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda, MD 4Institute for Cognitive and Computational Sciences, Georgetown University, Washington, DC, USA 2Present Address: Rotman Research Institute, Baycrest Centre for Geriatric Care, 3560 Bathurst St., Toronto, Ontario M6A 2E1, Canada 5Corresponding Author and Address: Cheryl L. Grady, Rotman Research Institute, Baycrest Centre for Geriatric Care, 3560 Bathurst St., Toronto, Ontario M6A 2E1, Canada ACKNOWLEDGEMENTS: The authors wish to thank Dr Francois Lalonde, David Mangot, Richard Desmond, and Eileen Daly for their technical help in carrying out this experiment. We also wish to thank Dr Claude Alain for his helpful comments on the manuscript. Received 8 April 1997; accepted 21 May 1997 NeuroReport: July 28th, 1997 - Volume 8 - Issue 11 - p 2511-2516 Buy Abstract WE investigated the effects of auditory attention on brain activity using functional magnetic resonance imaging. Subjects listened to three word lists, three times each, and were instructed to count the number of times they heard a target word during two of these presentations. For the third, they listened to the words without counting. All subjects showed significant areas of activation in auditory cortex during the listening conditions compared to rest. There was significantly more activation and a larger area of activation, particularly in association cortex, in the left temporal lobe during counting of targets compared to the no-target conditions, with a similar trend in the right hemisphere. These results provide evidence of an attention-related enhancement of both activation magnitude and extent in auditory cortex. © Lippincott-Raven Publishers.