Cognitive Neuroscience and Neuropsychology: PDF OnlyWhere the brain appreciates the moral of a storyNichelli, Paolo1,2; Grafman, Jordan1; Pietrini, Pietro3; Clark, Kimberley1; Lee, Kyu Young1; Miletich, Robert4,5Author Information 1Cognitive Neuroscience Section, NIH/NINDS/MNB, Building 10; Room 5S209, 10 Center Drive MSC 1440, Bethesda, Maryland 20892–1440, USA 2Clinical Neurologica, Universita' di Modena, Modena, italy 3Laboratory of Neurosciences, National Institutes on Aging 4Neuroimaging Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health 5Lucy Dent Imaging Center, Millard Fillmore Hospitals, Buffalo, NY, USA NeuroReport: November 27, 1995 - Volume 6 - Issue 17 - p 2309-2313 Buy Abstract To identify the distributed brain regions used for appreciating the grammatical, semantic and thematic aspects of a story, regional cerebral blood flow was measured with positron emission tomography in nine normal volunteers during the reading of Aesop's fables. In four conditions, subjects had to monitor the fables for font changes, grammatical errors, a semantic feature associated with a fable character, and the moral of the fable. Both right and left prefrontal cortices were consistently, but selectively, activated across the grammatical, semantic, and moral conditions. In particular, appreciating the moral of a story required activating a distributed set of brain regions in the right hemisphere which included the temporal and prefrontal cortices. These findings emphasize that story processing engages a widely distributed network of brain regions, a subset of which become preferentially active during the processing of a specific aspect of the text. © Lippincott-Raven Publishers.