Widespread functional disconnectivity in schizophrenia with resting-state functional magnetic resonance imaging : NeuroReport

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BRAIN IMAGING

Widespread functional disconnectivity in schizophrenia with resting-state functional magnetic resonance imaging

Liang, Menga; Zhou, Yuana; Jiang, Tianzia; Liu, Zheningb; Tian, Lixiaa; Liu, Haihongb; Hao, Yihuib

Author Information

aNational Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing

bInstitute of Mental Health, Second Xiangya Hospital, Central South University, Changsha, Hunan, PR China

Correspondence and requests for reprints to Prof. Tianzi Jiang, PhD, National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100080, PR China

Tel: +86 10 8261 4469; fax: +86 10 62551993; e-mail: [email protected]

Sponsorship: This work was partially supported by the Natural Science Foundation of China, Grant Nos 30425004 and 60121302, the National Key Basic Research and Development Program (973), Grant No. 2004CB318107.

Received 5 November 2005; accepted 15 November 2005

NeuroReport 17(2):p 209-213, February 6, 2006.

Abstract

Using resting-state functional magnetic resonance imaging, we examined the functional connectivity throughout the entire brain in schizophrenia. The abnormalities in functional connectivity were identified by comparing the correlation coefficients of each pair of 116 brain regions between 15 patients and 15 controls. Then, the global distribution of the abnormal functional connectivities was examined. Experimental results indicated, in general, a decreased functional connectivity in schizophrenia during rest, and such abnormalities were widely distributed throughout the entire brain rather than restricted to a few specific brain regions. The results provide a quantitative support for the hypothesis that schizophrenia may arise from the disrupted functional integration of widespread brain areas.

© 2006 Lippincott Williams & Wilkins, Inc.

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