BRAIN IMAGINGBrain regions involved in the recognition of happiness and sadness in musicKhalfa, Stéphanie; Schon, Daniele; Anton, Jean-Luc; Liégeois-Chauvel, Catherine Author Information INSERM EMI-U 9926, Laboratory of Neurophysiology and Neuropsychology, Marseille cedex, France Correspondence and requests for reprints to Dr Stéphanie Khalfa, PhD, Laboratoire de Neurophysiologie et Neuropsychologie, Inserm EMI-U 9926, Université de la Méditerranée, Faculté de médecine Timone, 27, Bd Jean Moulin, 13385 Marseille cedex 5, France Tel: +33 4 91 29 98 15; fax: +33 4 91 32 43 69; e-mail: [email protected] Received 30 September 2005; revised 10 October 2005; accepted 13 October 2005 NeuroReport 16(18):p 1981-1984, December 19, 2005. Buy Abstract Here, we used functional magnetic resonance imaging to test for the lateralization of the brain regions specifically involved in the recognition of negatively and positively valenced musical emotions. The manipulation of two major musical features (mode and tempo), resulting in the variation of emotional perception along the happiness–sadness axis, was shown to principally involve subcortical and neocortical brain structures, which are known to intervene in emotion processing in other modalities. In particular, the minor mode (sad excerpts) involved the left orbito and mid-dorsolateral frontal cortex, which does not confirm the valence lateralization model. We also show that the recognition of emotions elicited by variations of the two perceptual determinants rely on both common (BA 9) and distinct neural mechanisms. © 2005 Lippincott Williams & Wilkins, Inc.