Cognitive Neuroscience And NeuropsychologyLanguage-impaired children: No sign of the FOXP2 mutationMeaburn, E.CA; Dale, P. S.1; Craig, I. W.; Plomin, R. Author Information Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College London, 111 Denmark Hill, London SE5 8AF, UK 1Department of Communication Science and Disorders, University of Missouri-Columbia, Columbia, MO 65211, USA CACorresponding Author Received 18 February 2002 accepted 16 April 2002 Neuroreport 13(8):p 1075-1077, June 12, 2002. Buy Abstract A mutation in the FOXP2 gene has been found to be responsible for the autosomal dominant inheritance of a severe form of speech and language impairment in a family known as KE. We genotyped the FOXP2 mutation for 270 4-year-old children selected for low general language scores from a representative community sample of more than 18,000 children. No language-impaired child had the FOXP2 mutation. Although rare severe disorders such as those of the KE family are often caused by a single gene, common disorders such as language impairment are more likely to be the quantitative extreme of the same multiple genetic factors responsible for heritability throughout the distribution. © 2002 Lippincott Williams & Wilkins, Inc.