Over-expression of Pglycoprotein in malformations of cortical development : NeuroReport

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Glial Cells

Over-expression of Pglycoprotein in malformations of cortical development

Sisodiya, Sanjay M.; Heffernan, Josephine; Squier, Marian V.

Author Information

1Epilepsy Research Group, Institute of Neurology, University College London, Queen Square, London WC1N 3BG

2Department of Neuropathology, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK

3Corresponding Author: Sanjay M. Sisodiya

ACKNOWLEDGEMENTS: This work was supported by the Epilepsy Research Foundation, UK. We wish to thank Louise Young for her technical assistance.

Received 25 August 1999; accepted 11 September 1999

NeuroReport 10(16):p 3437-3441, November 8, 1999.

Abstract

DRUG resistance in epilepsy due to malformations of cortical development (MCD) is unexplained. P-glycoprotein is a mediator of drug resistance, and we propose that MCD lesions over-express P-glycoprotein. Because P-glycoprotein expression may be induced by some antiepileptic drugs (AEDs), we studied brain samples from MCD cases before the onset of seizures or treatment with AEDs. Sixteen MCD cases and 16 age-matched controls were examined using immunohisto-chemistry. Glial labelling, representing over-expression, was seen in 10 of 16 MCD samples and in two of 16 control samples (p = 0.003). Semiquantitative assessment showed many immunoreactive glia in five of 16 MCD and one of 16 controls. We conclude that there is constitutive over-expression of P-glycoprotein in many MCD.

© 1999 Wolters Kluwer Health | Lippincott Williams & Wilkins

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