Monitoring of anaesthesia in neurophysiological experiments : NeuroReport

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Neurophysiology

Monitoring of anaesthesia in neurophysiological experiments

Kral, A1,2; Tillein, J1; Hartmann, R1; Klinke, R1,3

Author Information

1Physiologisches Institut III, J.W.Goethe-Universität, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany

2Institute of Pathological Physiology, Comenius University Sasinkova 4, SK-81108 Bratislava, Slovak Republic

3Corresponding Author: R. Klinke

ACKNOWLEDGEMENTS: Drs Hans Roth (Zentrum der Anaesthesiologie, J.W.Goethe-Univ.) and Jean Smolders (Physiologisches Institut III, J.W.Goethe-Univ.) are thanked for helpful discussions on different aspects of the paper. Dr Silvia Heid is thanked for cooperation in the experiments. Supported by DFG (SFB 269).

Received 6 January 1999; accepted 13 January 1999

NeuroReport 10(4):p 781-787, March 17, 1999.

Abstract

Cortical activity can be substantially changed by the type of anaesthetic used, and by its dose level. For easy monitoring of depth of anaesthesia we describe the changes in electroencephalogram and electrocardiogram accompanying changes in depth of anaesthesia in the cat. Anaesthesia was induced by the volatile anaesthetic isoflurane. The high-frequency components (around 30 Hz) in the electroencephalogram disappear in deep anaesthesia. The electrocardiogram also shows substantial changes in contamination due to muscle fasciculations with anaesthesia level. Fasciculations appear as noise in the electrocardiogram. The amplitude of the electrical muscle activity contaminating the ECG can be easily used for the maintainance of a constant level of anaesthesia during a neurophysiological experiment.

© 1999 Lippincott Williams & Wilkins, Inc.

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