Inhibition of voltage-gated Ca2+ channels by antazolineMilhaud, Didier; Fagni, Laurent; Bockaert, Joël; Lafon-Cazal, MireilleCANeuroReport: October 7th, 2002 - Volume 13 - Issue 14 - p 1711-1714 MEMBRANE AND CELLULAR BIOPHYSICS AND BIOCHEMISTRY Buy SDC Abstract Author InformationAuthors We showed recently that imidazolines exert neuroprotection against hypoxia and NMDA toxicity in cerebellar and striatal neuronal cultures, through a voltage-dependent blockade of glutamatergic NMDA receptors. Here, we report that in striatal neuronal cultures from mouse embryos the imidazoline compound, antazoline, inhibits voltage-gated Ca2+ channels by acting at a phencycli-dine-like site. This effect was fast, fully reversible, voltage-dependent and predominant on P/Q- and N-type Ca2+ channels. Taken together, these results suggest that imidazolines may elicit neuroprotective effects also by decreasing the release of glutamate through inhibition of presynaptic Ca2+ channels. UPR CNRS 9023, CCIPE, 141, rue de la Cardonille, 34094 Montpellier Cedex 5, France CACorresponding Author: firstname.lastname@example.org Received 5 May 2002; accepted 10 July 2002 © 2002 Lippincott Williams & Wilkins, Inc.