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Oxygen-enhanced magnetic resonance imaging of the brain: a rodent model

Wu, Yingweia,b*; Gao, Xinc*; Feng, Xiaoyuand; Tao, Xiaofenga,b; Tang, Cheuk Yinge

Brain Imaging

Oxygen-enhanced MRI has been shown to be a viable alternative to hyperpolarized gases for pulmonary imaging. The changes in the relaxation times due to hyperoxic conditions in the blood pool induced by inhalation of pure oxygen have produced sufficient signal changes for imaging applications. This is a safe and low-cost alternative for contrast-enhanced imaging. The application of oxygen-enhanced MRI in brain imaging has been much less studied. In this study, we investigated the changes in the relaxation times in the brain due to inhalation of pure oxygen in a rodent model. We also assessed the effects of reduced blood flow due to hyperoxic conditions. Despite the reduced blood flow, significant changes in T1, T2, and T2* relaxation times were detected. We conclude that oxygen-enhanced MRI can be used in rodent models of disease.

aDepartment of Radiology, Shanghai East Hospital, School of Medicine, Tongji University

bDepartment of Radiology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University

cDepartment of Radiology, No. 85 Hospital

dDepartment of Radiology, Shanghai Huashan Hospital, School of Medicine, Shanghai Fudan University, Shanghai, China

eDepartment of Radiology, Mount Sinai School of Medicine, New York, New York, USA

*Yingwei Wu and Xin Gao contributed equally to the writing of this article.

Correspondence to Xiaofeng Tao, Shanghai East Hospital, Tongji University, 150 Jimo Road, Shanghai 200120, China Tel: +86 213 880 4518; fax: +86 213 880 4518; e-mail:

Received February 6, 2012

accepted March 12, 2012

© 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins