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Expression of connexin29 and 32 in the penumbra region after traumatic brain injury of mice

Moon, Younghyeb; Choi, So Yoena; Kim, Kyungjinb; Kim, Hyuna; Sun, Woonga

doi: 10.1097/WNR.0b013e32834051c7
CLINICAL NEUROSCIENCE AND NEUROPATHOLOGY
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Connexins (Cx) are transmembrane proteins forming vertebrate gap junction channels for direct cell–cell communication. We found that the expressions of two Cx family members, Cx29 and Cx32, were progressively increased in the sharp border of injury penumbra regions after cryotraumatic brain injury. Although these two Cxs are expressed exclusively in the oligodendrocytes in the normal cerebral cortex, their expressions were increased in the astrocytes and microglia localized in the injury border. Highly selective induction of Cxs in the injury border suggests that altered Cxs may contribute to the propagations of injury-related and/or regeneration signals after acute brain injury.

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aDepartment of Anatomy, Division of Brain Korea 21 Biomedical Science, Korea University College of Medicine

bBrain and Neuroendocrine Laboratory, School of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Korea

Correspondence to Woong Sun, PhD, Department of Anatomy, Division of Brain Korea 21 Biomedical Science, Korea University College of Medicine, 126-1, Anam-Dong, Sungbuk-Gu, Seoul 136-705, Korea Tel: +82 2 920 6404; fax: +82 2 929 5696; e-mail: woongsun@korea.ac.kr

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (www.neuroreport.com).

Received August 19, 2010

Accepted August 31, 2010

© 2010 Lippincott Williams & Wilkins, Inc.