Connexins (Cx) are transmembrane proteins forming vertebrate gap junction channels for direct cell–cell communication. We found that the expressions of two Cx family members, Cx29 and Cx32, were progressively increased in the sharp border of injury penumbra regions after cryotraumatic brain injury. Although these two Cxs are expressed exclusively in the oligodendrocytes in the normal cerebral cortex, their expressions were increased in the astrocytes and microglia localized in the injury border. Highly selective induction of Cxs in the injury border suggests that altered Cxs may contribute to the propagations of injury-related and/or regeneration signals after acute brain injury.
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aDepartment of Anatomy, Division of Brain Korea 21 Biomedical Science, Korea University College of Medicine
bBrain and Neuroendocrine Laboratory, School of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Korea
Correspondence to Woong Sun, PhD, Department of Anatomy, Division of Brain Korea 21 Biomedical Science, Korea University College of Medicine, 126-1, Anam-Dong, Sungbuk-Gu, Seoul 136-705, Korea Tel: +82 2 920 6404; fax: +82 2 929 5696; e-mail: firstname.lastname@example.org
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Received August 19, 2010
Accepted August 31, 2010