ArticlesMemory training alters hippocampal neurochemistry in healthy elderlyValenzuela, Michael J.1,2,CA; Jones, Megan1; Caroline Rae, Wei Wen3; Graham, Scott4; Shnier, Ronald4; Sachdev, Perminder1,2Author Information 1Neuropsychiatric Institute, The Prince of Wales Hospital, Euroa Centre, Randwick, NSW2031; 2School of Psychiatry,The University of New South Wales, Sydney; 3Department of Biochemistry, The University of Sydney; 4St George MRI, St George Hospital, Sydney, Australia CA,1Corresponding Author and Address: [email protected] Received 2 January 2003; accepted 12 February 2003 NeuroReport: July 18th, 2003 - Volume 14 - Issue 10 - p 1333-1337 doi: 10.1097/01.wnr.0000077548.91466.05 Buy Metrics Abstract Accumulating epidemiological evidence supports the notion of brain reserve, but there has been no investigation of neurobiological change associated with brief mental activation training in humans. Healthy older individuals were therefore investigated with magnetic resonance spectroscopy (MRS) in different brain regions before and after 5 weeks of focused memory training. Recall of a test-word list of > 23 items was achieved accompanied by elevation of creatine and choline signals in the hippocampus. Those at risk for neural dysfunction, as indicated by lower neurometabolites at baseline, demonstrated the largest MRS increases after training. Biochemical changes related to cellular energy and cell-membrane turnover were found to increase after structured memory exercises and were limited to the medial temporal lobe. NeuroReport 14:1333–1337 © 2003 Lippincott Williams & Wilkins. © 2003 Lippincott Williams & Wilkins, Inc.