ArticlesBilateral primary sensori-motor cortex activation of post-stroke mirror movements: an fMRI studyKim, Yun-Hee1; Jang, Sung HoCA; Chang, Yongmin2; Byun, Woo Mok3; Son, Soomin; Ahn, Sang HoAuthor Information 1Department of Physical Medicine and Rehabilitation, School of Medicine, Sungkyunkwan University, Samsung Medical Center, 50 Ilwon-dong, Kangnam-ku, Seoul, Republic of Korea, 135–710; 2Department of Diagnostic Radiology, College of Medicine Kyungbook National University, 2288, Samduk-dong, Jung-ku, Daegu, 750–030, Republic of Korea; Departments of Physical Medicine and Rehabilitation; 3Diagnostic Radiology, School of Medicine, Yeungnam University 317–1, Daemyung-dong, Nam-ku, Taegu, 705–717 CACorresponding Author: [email protected] Received 1 November 2002; accepted 3 April 2003 NeuroReport: July 18th, 2003 - Volume 14 - Issue 10 - p 1329-1332 doi: 10.1097/01.wnr.0000078702.79393.9b Buy Metrics Abstract This fMRI study was undertaken to test whether the pathophysiological mechanism of mirror movements in hemiparetic stroke patients involves activation of the unaffected motor cortex. We studied 16 control subjects and 51 stroke patients. fMRI was performed at 1.5Tusing a finger flexion-extension movement paradigm. The incidence of bilateral primary sensorimotor cortex activation was significantly increased during movements of the affected hand of stroke patients who showed mirror movements. Moreover, the incidence of bilateral primary sensorimotor cortex activation increased with the severity of mirror movements and primary sensorimotor cortex was activated bilaterally in all patients who showed sustained mirror movements.We conclude that the motor cortex activation on the non-stroke side is associated with mirror movements and is correlated with the severity of mirror movements. It seems that the pathophysiological mechanism of sustained mirror movements in stroke patients involves the unaffected motor cortex. NeuroReport 14:1329–1332 © 2003 Lippincott Williams & Wilkins. © 2003 Lippincott Williams & Wilkins, Inc.