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Caffeic acid produces antidepressive- and/or anxiolytic-like effects through indirect modulation of the α1A-adrenoceptor system in mice

Takeda, Hiroshi1,CA; Tsuji, Minoru1; Miyamoto, Junichi1,2; Masuya, Jiro3; Iimori, Makio3; Matsumiya, Teruhiko1

doi: 10.1097/01.wnr.0000073427.02536.b0
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We previously reported that caffeic acid produce antidepressiveand/or anxiolytic-like effects in two different types of stress models. It has recently been reported that caffeic acid affects the α1A-adrenoceptor system. The present study examined whether the α1A-adrenoceptor system is involved in the antidepressive- and/or anxiolytic-like effects of caffeic acid. Caffeic acid reduced the duration of immobility and freezing of mice produced by forced swimming and conditioned fear stress, respectively. These effects of caffeic acid were suppressed by the α1- and α1A-adrenoceptor antagonists. However, caffeic acid did not alter the binding of [3H]prazosin to α1A-adrenoceptor in mouse cortical membranes. These results suggest that indirect modulation of the α1A-adrenoceptor system may be involved in the antidepressive- and/or anxiolytic-like effects of caffeic acid.

1Department of Pharmacology and Intractable Diseases Research Center (Division of Drug Research and Development), Tokyo Medical University, 6–1–1 Shinjuku, Shinjuku-ku, Tokyo 160–8402; 2Medical Informatics, Tokyo Medical University, 6–1–1 Shinjuku, Shinjuku-ku, Tokyo 160–8402; 3Department of Psychiatry, Tokyo Medical University, 6–7–1 Nishishinjuku, Shinjuku-ku, Tokyo 160–0023, Japan

CACorresponding Author: ht0417@tokyo-med.ac.jp

Received 18 December 2002; accepted 18 February 2003

© 2003 Lippincott Williams & Wilkins, Inc.