Clinical NeuroscienceMore than static: altered dynamic functional connectivity of primary visual cortex in the comitant exotropia patientsChen, Juan*,; Chen, Wan Yun*,; Huang, Xin Author Information Department of Ophthalmology, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang 330006, Jiangxi, China Received 22 September 2022 Accepted 3 October 2022. *Juan Chen and Wan Yun Chen contributed equally to the writing of this article. Correspondence to Xin Huang, PhD, Department of Ophthalmology, Jiangxi Provincial People’s Hospital, No. 152, Ai Guo Road, Dong Hu District, Nanchang 330006, Jiangxi, China, Tel: +86 15879215294; e-mail: [email protected] NeuroReport: December 14, 2022 - Volume 33 - Issue 18 - p 812-818 doi: 10.1097/WNR.0000000000001849 Buy Metrics Abstract Previous neuroimaging studies have demonstrated that comitant exotropia (CE) patients exhibit dysfunction in various visual cortical areas. However, whether the CE patients showed abnormal dynamic functional connectivity (dFC) in primary visual cortex (V1) changes remains unknown. A total of 36 CE patients (25 males and 11 females) and 36 well-matched healthy control subjects (HCs) were enrolled in the study. The dFC with sliding window method was applied to investigate the dynamic functional connectivity changes in primary visual cortex (V1). Compared with HCs, CE patients had decreased dFC values between left V1 and right fusiform (Fus), right lingual (LING), left orbital medial frontal gyrus, left Fus, left calcarine and left precuneus (PreCUN). Meanwhile, CE patients had decreased dFC values between right V1 and left cerebelum_6 (CER_6), right lingual and left inferior occipital gyrus. Our study demonstrates that CE patients showed altered dFC within visual network and V1-default mode network, which might indicate the decreased variability FC values in the primary visual cortex in CE patients. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.