Clinical NeuroscienceThe connectivity between the olfactory and auditory cortex predicts an individual’s sleep qualityWang, Yinga,,b,,c; Zhou, Quand; Zhang, Weiwena; Niu, Chaoshia,,b,,cAuthor Information aDepartment of Neurosurgery, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China bAnhui Provincial Stereotactic Neurosurgical Institute cAnhui Province Key Laboratory of Brain Function and Brain Disease dHefei Central Sub-branch of the People’s Bank of China, Hefei, Anhui Province, People’s Republic of China Received 24 July 2020 Accepted 10 November 2020 Correspondence to Dr. Ying Wang, Department of Neurosurgery, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, Anhui Province, People’s Republic of China, Tel: +86 18019581668; e-mail: [email protected] NeuroReport: January 13, 2021 - Volume 32 - Issue 2 - p 99-104 doi: 10.1097/WNR.0000000000001567 Buy Metrics Abstract Sleep disorders and multiple sensory impairments have been noticed as the potential first sign of neurodegenerative diseases such as the Parkinson disease. The relationship between sleep quality and the sensory neural basis would help us consider their combination in early diagnosis. In the present study, 32 out of 45 healthy subjects’ resting-state functional magnetic resonance imaging data survived from motion correction and entered into the connectivity analysis. We found that the connectivity between two regions of interest (the left olfactory gyrus and the left superior temporal pole) and the regional homogeneity in the left middle temporal gyrus were negatively correlated with their Pittsburgh sleep quality index. These results suggest that these sensory-related brain regions are related to sleep quality and they may together predict the diseases. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.