Clinical NeuroscienceThe preattentive change detection in preschool children with attention deficit hyperactivity disorder: a mismatch negativity study.Zhang, Jinsonga; Qiu, Meihuia; Pan, Jingxuea; Zhao, LunbAuthor Information aDepartment of Medical Psychology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine and Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Shanghai bSchool of Educational Science, Liaocheng University, Liaocheng, China Received 6 November 2019 Accepted 22 April 2020 Correspondence to Lun Zhao, PhD, School of Educational Science, Liaocheng University, Liaocheng, China, Tel: +86 10 53352346; fax: +86 10 53352346; e-mail: email@example.com NeuroReport: July 10, 2020 - Volume 31 - Issue 10 - p 776-779 doi: 10.1097/WNR.0000000000001472 Buy Metrics Abstract To investigate the preattentive change detection in preschool children with attention deficit hyperactivity disorder (ADHD), we compared the mismatch negativity (MMN) and P3a of event-related potentials (ERPs) between preschool ADHD and normal children using three-stimulus oddball paradigm. Analyzing MMN and P3a components, we found that MMN elicited by deviants and P3a elicited by novelty were significantly reduced in patients than in controls. In addition, the P3a amplitude was positive correlated to IQ and negatively correlated to hyperactivity, antagonistic defiance and conduct problems in Swanson, Nolan, and Pelham IV Rating Scale, parent version. These data provided new neurophysiological evidence for the dysfunction of preattentive change detection and attentional shift in ADHD children. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.