Cellular, Molecular and Developmental NeuroscienceInhibition of phosphatidylinositol kinase-III alpha induces or facilitates lysosome exocytosis from microglia.Mu, Shujinga,,*; Lim, Nastasia K.-H.b,,*; Huang, FudecAuthor Information aShanghai Advanced Research Institute bShanghai Institute of Materia Medica cSino-Danish Center for Education and Research, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China *Shujing Mu and Nastasia K.-H. Lim contributed equally to the writing of this article. Received 15 July 2019 Accepted 2 September 2019 Correspondence to Fude Huang, Sino-Danish Center for Education and Research, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 201210, China, Tel/fax: +86 2120350962; e-mail: firstname.lastname@example.org NeuroReport: July 10, 2020 - Volume 31 - Issue 10 - p 697-701 doi: 10.1097/WNR.0000000000001348 Buy Metrics Abstract Besides degradation, lysosomes can also carry molecules for secretion out of the cell, such as ATP and cytokines, during unconventional secretion. Phosphatidylinositols and their metabolizing enzymes play important roles in the sorting and trafficking of lysosomal materials through the trans-Golgi network. The present study reveals a new function of phosphatidylinositol kinase-III alpha in the ‘kiss-and-run’ fusion of lysosomes at the plasma membrane to release ATP from microglia. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.