Integrative SystemsFunctional network analysis of the sub-regions of the primary motor cortex during restAlahmadi, Adnan A.S.Author Information Department of Radiologic Sciences, College of Applied Medical Sciences, King Abdulaziz University (KAU), Jeddah, Saudi Arabia Received 25 March 2020 Accepted 17 April 2020 Correspondence to Adnan Alahmadi, PhD, MRI and Neurosceince, Department of Radiologic Sciences, College of Applied Medical Sciences, King Abdulaziz University (KAU), Jeddah, Saudi Arabia, Tel: +00966 12 6400000; fax: +00966 12 6400000; e-mail: [email protected] NeuroReport: June 10, 2020 - Volume 31 - Issue 9 - p 691-695 doi: 10.1097/WNR.0000000000001470 Buy Metrics Abstract The cytoarchitectonic properties of the primary motor cortex have shown two distinct sub-regions: Anterior Broadmann area 4 (BA4a) and Posterior Broadmann area 4 (BA4p). Some previous studies have suggested that these two sub-regions are functionally different and showed that in few fMRI experiments, these sub-regions may have different roles in brain functions. Resting-state fMRI (rsfMRI) is advanced technique that allows investigating in detail the functional connectivity and provides a greater understanding of the physiological behavior of different brain regions. In this study, 198 healthy subjects were examined using a region-based rsfMRI analysis to investigate whether BA4a and BA4p have similar or different connections to other brain networks. The finding shows that indeed these two sub-regions have distinct connectivity to different brain networks. BA4a has a greater connection to motor-related areas while BA4p has connections to nonmotor-related areas (such as sensory, attentional, and higher order regions), suggesting that these two sub-regions should be considered as two separate regions of interests. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.