Cellular, Molecular and Developmental NeuroscienceConvolvulus pluricaulis extract can modulate synaptic plasticity in rat brain hippocampusDas, Rishia,,b; Sengupta, Tathagatab,,c; Roy, Shubhrajita; Chattarji, Sumantrac,,d,,e,,f; Ray, JharnaaAuthor Information aDepartment of Neuroscience, S. N. Pradhan Centre for Neurosciences, University of Calcutta bDepartment of Electrophysiology, TCG Lifesciences Pvt. Ltd., Bengal Intelligent Park, Tower-B, Block-EP & GP cCHINTA, TCG Centres for Research and Education in Science and Technology, Bengal Intelligent Park, Salt Lake Electronic Complex, Kolkata dNational Centre for Biological Sciences, Tata Institute of Fundamental Research eCentre for Brain Development and Repair, Institute for Stem Cell Biology and Regenerative Medicine, Bangalore, India fCentre for Discovery Brain Sciences, University of Edinburgh, EH8 9XD Edinburgh, UK Received 15 February 2020 Accepted 29 February 2020 Correspondence to Jharna Ray, PhD, S. N. Pradhan Centre for Neurosciences, University of Calcutta, Kolkata 700 019, India, Tel: +91 9433031773; fax: +91 33 24614849; e-mail: firstname.lastname@example.org NeuroReport: May 22, 2020 - Volume 31 - Issue 8 - p 597-604 doi: 10.1097/WNR.0000000000001446 Buy Metrics Abstract The memory-boosting property of Indian traditional herb, Convolvulus pluricaulis, has been documented in literature; however, its effect on synaptic plasticity has not yet been reported. Two important forms of synaptic plasticity known to be involved in the processes of memory formation are long-term potentiation (LTP) and long-term depression (LTD). In the present study, the effect of C. pluricaulis plant extract on LTP and LTD were evaluated. The adult male Wistar rats were fed orally with 250, 500 and 1000 mg/kg of this extract for 4 weeks and the effect was determined on LTP and LTD in the Schaffer collaterals of the hippocampal cornu ammonis region CA1. We found that the 500 mg/kg dose of the extract could significantly enhance LTP compared to the vehicle treated ones. Moreover, the same dose could also reduce LTD while used in a separate set of animals. Also, a fresh group of animals treated with the effective dose (500 mg/kg) of plant extract were examined for memory retention in two behavioral platforms namely, contextual fear conditioning (CFC) and novel object recognition test (NORT). Increased fear response to the conditioned stimulus and enhanced recognition of objects were observed in CFC and NORT, respectively, both indicating strengthening of memory. Following up, ex-vivo electrophysiology experiments were performed with the active single molecule scopoletin, present in C. pluricaulis extract and similar patterns in synaptic plasticity changes were obtained. These findings suggest that prolonged treatment of C. pluricaulis extract, at a specific dose in healthy animals, can augment memory functions by modulating hippocampal plasticity. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.