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Atorvastatin attenuates spinal cord injury by chronic fluorosis in rats

Shen, Qingfenga; Cao, Yangjingb; Xia, Yingpenga

doi: 10.1097/WNR.0000000000001351
Cellular, Molecular and Developmental Neuroscience
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The aim of the study was to explore the effect of atorvastatin on improvement of the function of the spinal cord in rats with chronic fluorosis. Sixty 3-month-old Wistar rats were separated randomly into three groups: normal group (N group), control group (C group) and atorvastatin group (A group). The Basso Beattie and Bresnahan scale and oblique board test showed that the rats in A group got higher score and better hind-limb motor function than C group. Immunohistochemistry and western blotting revealed that compared with N group, matrix metalloproteinase 9 (MMP-9) and p53 were highly expressed and myelin basic protein (MBP) was low expressed in spinal cord of C group. Meanwhile, MMP-9 and p53 expression were decreased and MBP was upregulated by atorvastatin compared with C group. In conclusion, the improvement of the function of the spinal cord in rats can be found when they were treated with atorvastatin.

aDepartment of Spine Surgery, Tianjin Union Medical Center

bGraduate school of Tianjin Medical University, Tianjin, China

Received 5 August 2019 Accepted 4 September 2019

Correspondence to Yingpeng Xia, Department of Spine Surgery, Tianjin Union Medical Center, Tianjin 300121, China, Tel: +86 022 27557261; fax: +86 22 27557261; e-mail: xiayingpeng3755@163.com

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