Clinical NeuroscienceThe relationship between resting electroencephalogram oscillatory abnormalities and schizotypal personality traits in the first-degree relatives of schizophrenia patientsChen, Chena,,*; Huang, Weia,,*; Chen, Xianjunb,,*; Shi, Xiufangc; Zhu, Xiquanb; Ma, Wentaod; Wang, Yapei; Kang, Qie; Wang, Xiuchaoa; Guan, Muzhenf; Huang, Hea; Wu, Shengjuna,,†; Liu, Xufenga,,†Author Information aDepartment of Military Medical Psychology, Fourth Military Medical University (Air Force Medical University), Xi’an bDepartment of Psychiatry, Mental Diseases Prevention and Treatment Institute of PLA, No. 988 Hospital of Joint Logistic Support Force of PLA, Jiaozuo cThe Fourth Department of Psychiatry, No. 984 Hospital of Joint Logistic Support Force of PLA, Beijing dDepartment of Psychiatry, Mental Diseases Prevention and Treatment Institute of PLA, No. 987 Hospital of Joint Logistic Support Force of PLA, Baoji eYouth and Children’s Psychological Center, No. 904 Hospital of Joint Logistic Support Force of PLA, Changzhou fDepartment of Mental Health, Xi’an Medical University, Xi’an, China *Dr. Chen Chen, Dr. Wei Huang and Dr. Xianjun Chen contributed equally to the writing of this article. †Shengjun Wu and Xufeng Liu are co-authors. Received 5 May 2019 Accepted 4 September 2019 Correspondence to Xufeng Liu, PhD, Department of Military Medical Psychology, Fourth Military Medical University, No. 169 West Changle Road, Xi’an 710032, China, Tel: +86 029 84779309; fax: +86 029 84779309; e-mail: [email protected] NeuroReport: December 10, 2019 - Volume 30 - Issue 17 - p 1215-1221 doi: 10.1097/WNR.0000000000001350 Buy Metrics Abstract Although a large amount of studies have manifested resting state electroencephalogram oscillatory abnormalities in schizophrenia and their first-degree relatives and in schizotype, the results are far from consistent and no research found any relationship between electroencephalograph (EEG) abnormalities and schizotypal personality in first-degree relatives. The present study is to verify the modifications of EEG power spectra in eyes-open resting state of schizophrenia and first-degree relatives, and to investigate associations between EEG band power and schizotypal personality traits in first-degree relatives of schizophrenia patients. Participant samples in this study consisted of 33 healthy normal controls, 35 unaffected first-degree relatives of schizophrenia patients and 35 schizophrenia patients. Group differences in resting EEG band power were examined via repeated-measures analysis of variance, and correlation between EEG power and schizotypal personality traits via Pearson Correlation analysis. The results showed that patients with schizophrenia exhibited increased delta, theta and alpha activity over anterior and central regions in eyes-open resting state compared with that of normal control. Gamma band power was found for the first time to be negatively correlated to schizotypal personality traits in first-degree relatives of schizophrenia patients. To conclusion, these findings suggested that low-frequency EEG activity might be neural manifestations of pathophysiological changes in the brain of schizophrenia, and gamma band activity might be an approach to measure the genetic liability of the disorder. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.