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Protective effects of polygalasaponin F on oxidative stress and apoptosis-induced ischemic myocardial injury in neonatal rats with hypoxic-ischemic brain damage

Zhou, Wen-Lia; Zhang, Jian-Taob; Xu, Weia; Sun, Jing-Huia

doi: 10.1097/WNR.0000000000001330
Degeneration and Repair
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The aim of the present study was to evaluate the role of polygalasaponin F on ischemic myocardial injury in neonatal rats with hypoxic-ischemic brain damage. A primary in-vitro myocardial cell oxygen-glucose deprivation/reperfusion model and an in-vivo middle cerebral artery occlusion model were established. The results demonstrated that polygalasaponin F protects myocardium in hypoxic-ischemic brain injury. The mechanisms of its protective effect involved in (1) reducing oxidant stress injury, (2) reducing the apoptosis rate of myocardial cells through increasing the Bcl-2 protein level and decreasing the Cyt-C and Bax values, and (3) alleviating liver and kidney damage caused by cerebral hypoxia and ischemia via reducing the damage markers. The results of the present study may contribute toward the development of novel strategies for clinical cardioprotection with hypoxic-ischemic brain damage.

Departments of aPediatrics

bAno-colorectal surgery, The First Hospital of Jilin University, Changchun, Jilin, People’s Republic of China

Received 24 July 2019 Accepted 8 August 2019

Correspondence to Professor Jing-hui Sun, Department of Pediatrics, The First Hospital of Jilin University, 71 Xinmin Road, Changchun, Jilin 130000, People’s Republic of China, Tel/fax: +0431 88782222; E-mail: sunjinghui2558@126.com

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