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Lesion of the dorsal hippocampus alters the time–course evolution of corticosterone rise in the ventral hippocampus after stress

Piérard, Christophea,*; Dorey, Rodolphea,*; Corio, Marcb; Béracochéa, Danielb

doi: 10.1097/WNR.0000000000001263
INTEGRATIVE SYSTEMS
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We previously showed that an acute stress-induced an early corticosterone rise in the dorsal hippocampus (dHPC) and a delayed one in the ventral hippocampus (vHPC). Congruently, we hypothesized that the dHPC may influence the time–course evolution of poststress glucocorticoid rise in the vHPC. To probe this issue, we performed ibotenic acid lesions of the dHPC and measured by microdialysis the time–course evolution of corticosterone rise in the vHPC after an acute stress delivery. In nonstress condition, we showed that the dHPC lesion induced a significant increase of corticosterone both in plasma and in the vHPC. In addition, an acute stress (electric footshocks) induced a faster and more sustained corticosterone rise in the vHPC of dHPC-lesioned animals, as compared to sham-operated ones. This study provides new found evidence to the effect that the dHPC lesion alters the time–course evolution of corticosterone rise within the vHPC after stress.

aBiomedical Research Institute of the Armies, Bretigny-sur Orge

bNational Center of Scientific Research 5287 Unit, University of Bordeaux, Pessac, France

* Christophe Piérard and Rodolphe Dorey contributed equally to the writing of this article.

Correspondence to Daniel Beracochea, PhD, National Center of Scientific Research 5287 Unit, University of Bordeaux, Avenue G. St-Hilaire Bat B2, 33615 Pessac, France Tel: +33 540 002 439; fax: +33 540 008 743; e-mail: daniel.beracochea@u-bordeaux.fr

Received March 12, 2019

Accepted April 12, 2019

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