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Expressions of miR-132, miR-134, and miR-485 in rat primary motor cortex during transhemispheric functional reorganization after contralateral seventh cervical spinal nerve root transfer following brachial plexus avulsion injuries

Wang, Xin-Honga,*; Li, Li-Junc,*; Sun, Gui-Xind; Wu, Zuo-Peid; Li, Ji-Fengb; Gu, Yu-Dongb

doi: 10.1097/WNR.0000000000000485
CELLULAR, MOLECULAR AND DEVELOPMENTAL NEUROSCIENCE
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The transfer of a contralateral healthy seventh cervical spinal nerve root (cC7) to the recipient nerve in the injured side is considered a promising procedure for restoration of the physiological functions of an injured hand after brachial plexus root avulsion injury (BPAI). Growing evidence shows that transhemispheric cortical reorganization plays an important role in the functional recovery of the injured arm after cC7 nerve transfer surgery. However, the molecular mechanism underlying the transhemispheric cortical reorganization after cC7 transfer remains elusive. In the present study, we investigated the expression of miR-132, miR-134, and miR-485 in the rat primary motor cortex after cC7 transfer following BPAI by quantitative PCR. The results demonstrated the dynamic alteration in the expression of miR-132, miR-134, and miR-485 in the primary motor cortex of rats after cC7 transfer following BPAI. It indicates that microRNAs are involved in the dynamic transhemispheric functional reorganization after cC7 root transfer following BPAI. Together, this study is the first to provide evidence for the involvement of microRNAs during dynamic transhemispheric functional reorganization after cC7 transfer following BPAI. The results are useful for understanding the mechanism underlying transhemispheric functional reorganization after contralateral seventh cervical spinal nerve root transfer following BPAI.

aDepartment of Physiology & Pathophysiology, School of Basic Medical Sciences

bDepartment of Hand Surgery, Huashan Hospital, Fudan University

cDepartment of Spine Surgery

dDepartment of Traumatology, Shanghai East Hospital, Tongji University, Shanghai, People’s Republic of China

* Xin-Hong Wang and Li-Jun Li contributed equally to the writing of this article.

Correspondence to Gui-Xin Sun, MD, PhD, Department of Traumatology, Shanghai East Hospital, Tongji University, 150 Jimo Road, PuDong New District, Shanghai 200120, People’s Republic of China Tel: +86 21 3880 4518; fax: +86 21 5879 8999; e-mail: dfyysgx2014@163.com

Received September 28, 2015

Accepted October 2, 2015

© 2016 Wolters Kluwer Health | Lippincott Williams & Wilkins