The aim of this study was to evaluate the white matter (WM) volume change and its correlation with symptom severity in patients with schizophrenia using voxel-based morphometry. A total of 20 patients with schizophrenia and 20 age-matched healthy controls participated in this study. MR image data were processed using SPM8 software with diffeomorphic anatomical registration through an exponentiated Lie algebra (DARTEL) algorithm. The patients with schizophrenia showed significant decreases (P=0.042) in the WM volumes of the temporal lobe and superior frontal gyrus compared with the healthy controls. The WM volumes of the middle temporal gyrus were negatively correlated with the scores of both the Positive Subscale (Pearson’s ρ=−0.68, P=0.001) and the Negative Subscale (ρ=−0.71, P=0.0005) in the Positive and Negative Syndrome Scale. In addition, the scores of the General Psychopathology Subscale were negatively correlated with the WM volumes of the superior frontal gyrus (ρ=−0.68, P=0.0009). This study evaluated the WM volume of patients with schizophrenia compared with healthy controls using DARTEI-based voxel-based morphometry and also assessed the correlation of the localized WM volume changes with the Positive and Negative Syndrome Scale. These findings will be useful to understand the neuropathology associated with WM abnormality in schizophrenia.
aResearch Institute for Medical Imaging
bDepartment of Radiology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Republic of Korea
Correspondence to Gwang-Woo Jeong, MPH, PhD, Department of Radiology, Chonnam National University Hospital, Chonnam National University Medical School, 42 Jebong-Ro, Donggu, Gwangju 501-757, Republic of Korea Tel: +82 62 220 5881; fax: +82 62 226 4380; e-mail: firstname.lastname@example.org
Received July 15, 2015
Accepted September 22, 2015