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Task dependency of the long-latency facilitatory effect on the soleus H-reflex by cerebellar transcranial magnetic stimulation

Matsugi, Akiyoshi; Mori, Nobuhiko; Uehara, Shintaro; Kamata, Noriyuki; Oku, Kosuke; Mukai, Kouichi; Nagano, Kiyoshi

doi: 10.1097/WNR.0000000000000275

We investigated whether cerebellar transcranial magnetic stimulation (C-TMS) facilitates the excitability of the ipsilateral soleus motoneuron pool in resting humans, and whether the facilitation is modulated by a task that promotes cerebellar activity. A test tibial nerve stimulus evoking the H-reflex from the right soleus muscle was delivered before or after conditioning C-TMS in prone individuals. The amplitude of the H-reflex was significantly increased at conditioning-test interstimulus intervals of 110, 120, and 130 ms. Furthermore, we revealed that this facilitation effect was inhibited while the individuals tapped their right index finger. These findings indicate that C-TMS facilitates spinal motoneuronal excitability with an ∼100 ms latency in resting humans, and that this cerebellar spinal facilitation is modulated by a task that might increase cerebellar activity. Cerebellar spinal facilitation could thus be useful for assessing the excitability of the cerebellum, or the cerebellar output to spinal motoneurons.

aFaculty of Rehabilitation, Shijonawate Gakuen University

bCenter for Information and Neural Networks, National Institute of Information and Communications Technology

cRehabilitation Unit, Osaka University Hospital, Osaka

dDepartment of Rehabilitation, Yamamoto Hospital, Wakayama

eJapan Society for the Promotion of Science, Tokyo

fDepartment of Rehabilitation, Hannachuo Hospital, Nara, Japan

Correspondence to Akiyoshi Matsugi, PhD, Faculty of Rehabilitation, Shijonawate Gakuen University, Hojo 5-11-10, Daitou City, Osaka 574-0011, Japan Tel: +81 72 863 5043; fax: +81 72 863 5022; e-mail:

Received August 19, 2014

Accepted September 5, 2014

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins