DEGENERATION AND REPAIRTreadmill exercise elevates striatal dopamine D2 receptor binding potential in patients with early Parkinson’s diseaseFisher, Beth E.a,d; Li, Quanzhengb; Nacca, Angeloc; Salem, George J.a,d; Song, Jooeuna; Yip, Jeaninea; Hui, Jennifer S.d; Jakowec, Michael W.a,d; Petzinger, Giselle M.a,d Author Information aDivision of Biokinesiology and Physical Therapy bViterbi School of Engineering Departments of cRadiology dNeurology, University of Southern California, Los Angeles, California, USA Correspondence to Giselle M. Petzinger, MD, Department of Neurology, 1333 San Pablo St., MCA-241, University of Southern California, Los Angeles, CA 90033, USA Tel: +1 323 442 1057; fax: +1 323 442 1055; e-mail: [email protected] Received March 14, 2013 Accepted April 2, 2013 NeuroReport 24(10):p 509-514, July 10, 2013. | DOI: 10.1097/WNR.0b013e328361dc13 Buy Metrics Abstract We have previously demonstrated changes in dopaminergic neurotransmission after intensive exercise in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of Parkinson’s disease (PD), including an increase in the dopamine D2 receptor (DA-D2R), using noninvasive PET imaging with the radioligand [18F]fallypride. The purpose of this feasibility and translational study was to examine whether intensive exercise leads to similar alterations in DA-D2R expression using PET imaging with [18F]fallypride in individuals with early-stage PD. In this pilot study, four patients with early-stage PD were randomized to receive intensive exercise (treadmill training sessions three times/week for 8 weeks) or no exercise. Two healthy age-matched individuals participated in treadmill training. Alterations in the DA-D2R binding potential (BP) as a marker for receptor expression were determined using PET imaging with [18F]fallypride. Turning performance in the patients with PD as a measure of postural control and the Unified Parkinson’s Disease Rating Scale scores pre-exercise and postexercise were determined. Our data showed an exercise-induced increase in [18F]fallypride BP as well as improved postural control in patients with PD who exercised. Changes in DA-D2R BP were not observed in patients with PD who did not exercise. These results suggest that exercise can lead to neuroplasticity in dopaminergic signaling and contribute to improved function that may be task specific (postural control) in early-stage PD. © 2013 Lippincott Williams & Wilkins, Inc.