ALZHEIMER’S DISEASENo association of SORT1 gene polymorphism with sporadic Alzheimer’s disease in the Chinese Han populationZeng, Fana,*; Deng, Yong-Pingb,*; Yi, Xua; Cao, Hong-Yuana; Zou, Hai-Qiangc; Wang, Xina; Liang, Chun-Ronga; Wang, Ye-Rana; Zhang, Li-Lia; Gao, Chang-Yuea; Xu, Zhi-Qianga; Lian, Yana; Wang, Lina; Zhou, Xin-Fud; Zhou, Hua-Donga; Wang, Yan-JiangaAuthor Information aDepartment of Neurology and Center for Clinical Neuroscience, Daping Hospital and Institute of Field Surgery, Third Military Medical University, Chongqing bHome for the Aged Guangzhou cDepartment of Neurology, The General Hospital of Guangzhou Military Command, Guangzhou, China dSchool of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, Australia Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's website (www.neuroreport.com). *Fan Zeng and Yong-Ping Deng contributed equally to the writing of this article. Correspondence to Yan-Jiang Wang, MD, PhD, Department of Neurology and Center for Clinical Neuroscience, Daping Hospital and Institute of Field Surgery, Third Military Medical University, 10 Changjiang Branch Road, Yuzhong District, Chongqing 400042, China Tel: +86 15023653506; fax: +86 68711956; e-mail: [email protected] Received March 6, 2013 Accepted March 19, 2013 NeuroReport: June 19, 2013 - Volume 24 - Issue 9 - p 464-468 doi: 10.1097/WNR.0b013e3283619f43 Buy SDC Metrics Abstract Increasing evidence shows that sortilin (encoded by SORT1 gene), a member of the vacuolar protein sorting 10 family of sorting receptors, can modulate amyloid-β peptides (Aβ) metabolism and clearance, as well as mediate the neurotoxicity of the Aβ oligomer and proneurotrophins, thus playing diverse roles in the pathogenesis of Alzheimer’s disease. To assess the association between single nucleotide polymorphism (SNP) of the SORT1 gene and sporadic Alzheimer’s disease (sAD) in the Chinese Han population, a case–control study was carried out including 220 sAD patients and 245 controls. One tag SNP was selected from the entire SORT1 gene through construction of linkage disequilibrium blocks, and three SNPs located in the vicinity of SORT1 that affect its expression were also selected. The four target SNPs were genotyped using a multiplex PCR-ligase detection reaction method, yielding no significant association between them or haplotypes containing three of them, and the risk of sAD. The results of this study indicate that polymorphisms of the SORT1 gene are unlikely to confer the risk of sAD in the Chinese Han population. © 2013 Lippincott Williams & Wilkins, Inc.