SOMATOSENSORY SYSTEMS, PAINContribution of sensory C-fiber neuron injury to mechanical dynamic allodynia in a murine model of postherpetic neuralgiaSasaki, Atsushia; Inomata, Yujib; Serizawa, Kenichia; Andoh, Tsugunobua; Kuraishi, YasushiaAuthor Information aDepartment of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama bPharmacology Research Laboratories I, Department II, Research Division, Mitsubishi Tanabe Pharma Corporation, Yokohama, Japan Correspondence to Yasushi Kuraishi, PhD, Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan Tel: +81 76 434 7510; fax: +81 76 434 5045; e-mail: firstname.lastname@example.org Received October 2, 2012 Accepted December 12, 2012 NeuroReport: February 13th, 2013 - Volume 24 - Issue 3 - p 137-141 doi: 10.1097/WNR.0b013e32835df4d9 Buy Metrics Abstract Mechanical dynamic allodynia is a hallmark symptom of postherpetic neuralgia, but the mechanisms are unclear. This study examined the participation of injury to sensory C-fiber and A-fiber neurons in postherpetic dynamic allodynia. Percutaneous inoculation of mice with herpes simplex virus type-1 caused zoster-like skin lesions and dynamic allodynia, which persisted after lesion healed. In postherpetic mice, the intensity of dynamic allodynia was positively and negatively correlated with the withdrawal latency of nociceptive response to heat and the intensity of aversive response to capsaicin, respectively. Calcitonin gene-related peptide immunoreactivity (a C-fiber marker) was markedly reduced, but neurofilament 200 immunoreactivity (an A-fiber neuron marker) was unchanged in the scarred skin of postherpetic mice. In the affected dorsal root ganglion of postherpetic mice, peripherin-immunoreactive (a C-fiber neuron marker) neurons reduced significantly, whereas neurofilament 200-immunoreactive neurons did not. These results suggest that postherpetic dynamic allodynia is associated with injury to sensory C-fiber neurons and little damage to A-fiber neurons. © 2013 Lippincott Williams & Wilkins, Inc.