VISION, CENTRALNeuronal response specificity as a marker of reading proficiency two-fold nature of the N170 revealed after massive repetitionKorinth, Sebastian P.a,b; Sommer, Wernerc; Breznitz, Zviad Author Information aGerman Institute for International Educational Research bCenter for Individual Development and Adaptive Education of Children at Risk (IDeA), Frankfurt am Main cDepartment of Psychology, Humboldt University at Berlin, Berlin, Germany dEdmond J. Safra Brain Research Center for the Study of Learning Disabilities University of Haifa, Haifa, Israel Correspondence to Sebastian P. Korinth, PhD, German Institute for International Educational Research, Schloßstraße 29, 60486 Frankfurt am Main, Germany Tel: +49 69 24708 731; fax: +49 69 24708 216; e-mail: [email protected] Received November 25, 2012 Accepted November 27, 2012 NeuroReport: January 23, 2013 - Volume 24 - Issue 2 - p 96-100 doi: 10.1097/WNR.0b013e32835d20b1 Buy Metrics Abstract Reading demands precise and efficient letter and word processing. This event-related potentials (ERP) study utilized massive repetition of visually presented single letters to trigger neuronal adaptation. Our aim was to explore whether the adaptation pattern of the N170 ERP component, serving as an indicator of neuronal response specificity, would differ for two reader groups. Forty German students, divided at the median into slow and fast readers, accomplished a visual oddball paradigm. ERPs of standard stimuli were computed separately for the first, second, and third part of the experiment. ERP waveforms and independent component analyses showed two subcomponents within the N170 time window. For both reader groups, the ERP amplitudes decreased over the time course of the experiment; however, only faster readers showed a subcomponent-specific adaptation response, restricted to the earlier N170 part. Results may reflect different degrees of neuronal response specificity in slow and fast readers, which might serve as a promising indicator for interindividual differences in visual recognition tasks such as reading. © 2013 Lippincott Williams & Wilkins, Inc.