BEHAVIORAL, INTEGRATIVE AND CLINICAL NEUROSCIENCEAltered resting state functional connectivity patterns of the anterior prefrontal cortex in obsessive-compulsive disorderLi, Pinga,c; Li, Sufangb; Dong, Zhangyeb; Luo, Jiaa; Han, Haiyinga; Xiong, Hongfanga; Guo, Zhihuaa; Li, ZhanjiangaAuthor Information aDepartment of Psychiatry, Beijing Anding Hospital, Capital Medical University bState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing cDepartment of Psychiatry, Qiqihaer Medical College, Qiqihaer, Heilongjiang, China Correspondence to Zhanjiang Li, MD, PhD, Department of Psychiatry, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China Tel: +86 10 58 303 004; fax: +86 10 58 303 004; e-mail: [email protected] Received March 14, 2012 Accepted May 8, 2012 NeuroReport: August 1, 2012 - Volume 23 - Issue 11 - p 681-686 doi: 10.1097/WNR.0b013e328355a5fe Buy Metrics Abstract In this study, we explored different spontaneous functional connectivity patterns between the anterior prefrontal cortex and other brain regions in nonmedicated patients with obsessive-compulsive disorder in a resting state, and examined the relationship between the abnormal spontaneous functional connectivity patterns of the anterior prefrontal cortex and clinical symptoms in patients with obsessive-compulsive disorder. Twenty nonmedicated patients with obsessive-compulsive disorder and 20 sex-matched and age-matched healthy individuals underwent resting state functional MRI scanning. Compared with the healthy controls, significantly increased positive functional connectivity with the right anterior prefrontal cortex was observed in the right insula and the middle cingulate cortex in patients with obsessive-compulsive disorder. Our findings suggest that abnormal intrinsic or spontaneous functional connectivity in the cognitive control system in a resting state may underlie the pathophysiology of obsessive-compulsive disorder. © 2012 Lippincott Williams & Wilkins, Inc.