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Dopamine stimulates epidermal growth factor release from adult neural precursor cells derived from the subventricular zone by a disintegrin and metalloprotease

O’Keeffe, Gráinne C.; Barker, Roger A.

doi: 10.1097/WNR.0b013e32834d2f65
CELLULAR, MOLECULAR AND DEVELOPMENTAL NEUROSCIENCE
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Dopamine plays a key role in the regulation of stem cell turnover and neurogenesis in the subventricular zone. This effect is mediated by dopamine-induced release of epidermal growth factor (EGF), to promote stem cell proliferation in this area. We, therefore, sought to investigate whether a disintegrin and metalloprotease (ADAMs) are implicated in this process, as they have previously been shown to play a role in transactivation of the EGF receptor after stimulation of G protein-coupled receptors. We found that dopamine stimulation of stem cells caused the release of EGF, in agreement with our previous findings. However, the inhibition of ADAMs reversed this effect. Our results support a role for ADAMs in dopamine-induced release of EGF from stem cells in the subventricular zone.

Department of Clinical Neurosciences, Cambridge Centre for Brain Repair, University of Cambridge, Forvie Site, Robinson Way, Cambridge, UK

Correspondence to Gráinne C. O’Keeffe, Department of Clinical Neurosciences, Cambridge Centre for Brain Repair, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 0PY, UK Tel: +0044 1223 331160; fax: +0044 1223 331174; e-mail: grainne_okeeffe@hotmail.com

Received August 25, 2011

Accepted September 14, 2011

© 2011 Lippincott Williams & Wilkins, Inc.