Cadherins, cell adhesion molecules widely expressed in the nervous system, are thought to be involved in synapse formation and function. To explore the role of cadherins in neuronal activity, we performed electrophysiological and morphological analyses of rat hippocampal cultured neurons overexpressing type-II cadherins, such as cadherin-6B and cadherin-7. We found that cadherin-6B increased but cadherin-7 decreased the number of protrusions of dendritic spines, and affected the frequency of miniature excitatory postsynaptic currents. Our results suggest that type-II cadherins may modulate neural activity by regulating neuronal morphology.
Supplemental Digital Content is available in the text
aLaboratory for Biolinguistics
bLaboratory for Symbolic Cognitive Development, RIKEN Brain Science Institute, Wako
cJST, ERATO, Okanoya Emotional Information Project, Wako
dDivision of Life Science, Graduate School of Science and Engineering, Saitama University, Saitama
eDepartment of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Tokyo, Japan
Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (www.neuroreport.com).
Correspondence to Tohru Kurotani, JST, ERATO, Okanoya Emotional Information Project, Hirosawa 2-1, Wako, 351-0198 Japan and Kazuo Okanoya, RIKEN Brain Science Institute, Hirosawa 2-1, Wako, 351-0198 Japan Tel: +81 48 462 1111×6823; fax: +81 48 467 7503; e-mail: email@example.com; firstname.lastname@example.org
Received May 13, 2011
Accepted May 23, 2011