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Histone H3 phosphoacetylation is critical for heroin-induced place preference

Sheng, Jiana; Lv, Zhi ganga; Wang, Leia; Zhou, Yuqinga; Hui, Binb

doi: 10.1097/WNR.0b013e328348e6aa

We investigated the role of histone H3 phosphoacetylation in the nucleus accumbens (NAc) in heroin-conditioned place preference paradigm. Heroin could dose-dependently increase histone H3 phosphoacetylation specifically in the NAc and could enhance heroin place preference. Injection of trichostatin A into the NAc significantly augmented heroin-induced histone H3 phosphoacetylation and enhanced heroin place preference. Conversely, injection of MK-801 into the NAc attenuated histone H3 phosphoacetylation and reduced heroin place preference. These data suggest that histone H3 phosphoacetylation in the NAc may play a critical role in heroin addiction.

aPharmacology Research Center and the State Key Laboratory of Medical Neurobiology, Shanghai Medical College and Institutes of Brain Science, Fudan University, Shanghai

bDepartment of Pharmacology, College of Medicine, Jiaxing University, Jiaxing, Zhejiang, China

Correspondence to Yuqing Zhou, Pharmacology Research Center, Fudan University, 138 Yixueyuan Road, Shanghai, 200032, China and Dr Bin Hui, PhD, Department of Pharmacology, College of Medicine, Jiaxing University, PO Box 314001, Jiaxing, Zhejiang, China Tel/fax: +86 21 54237621; e-mail:

Received April 4, 2011

Accepted May 17, 2011

© 2011 Lippincott Williams & Wilkins, Inc.