Vagus nerve comprises two distinct kinds of nerves, nodose and jugular ganglionic nerves. We tested pharmacological difference between two vagal nerves in the responsiveness to FMRFamide. The response probability to FMRFamide was significantly higher in nodose than jugular nerves in intracellular calcium measurement. Nodose nerves also depolarized membrane potential to FMRFamide more than jugular nerves did, in patch-clamp recording, although the probability of action potential discharge was same in both nerves. The inward current induced by FMRFamide was characterized as mixed cations. These results suggest that FMRFamide may act as an activator and modulator of vagal sensory nerves for treating symptoms in visceral diseases.
aDepartments of Physiology
bAnesthesiology, Korea University College of Medicine, Seoul, Republic of Korea
cAsthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Correspondence to Min-Goo Lee, MD, PhD, Department of Physiology 3205, Korea University College of Medicine, 126-1 Anam5ga, Sungbukgu, Seoul 136-705, Republic of Korea Tel: +82 2 920 6194; fax: +82 2 925 5492; e-mail: email@example.com
Received May 25, 2011
Accepted May 29, 2011