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Spinal metabotropic glutamate receptor 4 is involved in neuropathic pain

Wang, Huaa,b; Jiang, Weia; Yang, Ruic; Li, Yongb

doi: 10.1097/WNR.0b013e3283453843

Glutamate receptors (GluRs) play a critical role in pain pathway. Recent studies have shown that activation of spinal group III metabotropic GluRs attenuated hyperalgesia in neuropathic pain model rats. However, it is unclear which subtype of group III metabotropic GluRs is involved in neuropathic pain. In this study, we have shown that spinal administration of metabotropic GluRs (mGluR4)-positive allosteric modulator (VU0155041) dose dependently attenuated hyperalgesia in neuropathic pain model rats, whereas that of mGluR7-positive allosteric modulator (AMN082) did not. Furthermore, we confirmed that it was mGluR4 not mGluR7, whose expression was downregulated in the spinal dorsal horn after spinal nerve ligation. Thus, these results suggest the alteration of the spinal mGluR4 expression that contributes to the development of neuropathic pain.

aDepartment of Anesthesiology, Shanghai Sixth People's Hospital

bDepartments of Neurobiology

cPharmacy, Shanghai Jiao Tong University, School of Medicine, Shanghai, China

Correspondence to Wei Jiang, MD, PhD, Department of Anesthesiology, Shanghai Sixth People's Hospital, Shanghai Jiaotong University, 600 Yi Shan Road, Shanghai 200233, China Tel: +86 21 64369181 8328; fax: +86 21 64369181 8330; e-mail:

Received December 9, 2010

Accepted January 28, 2011

© 2011 Lippincott Williams & Wilkins, Inc.