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Focal transient ischemia increases APP-BP1 expression in neural progenitor cells

Joo, Yuyounga; Lee, Sang Hyungb; Ha, Sungjia; Hong, Bo-Hyuna; Kim, Joung-Hund; Suh, Yoo-Huna; Kim, Hye-Suna,c

doi: 10.1097/WNR.0b013e32834449cf

Amyloid precursor protein binding protein-1 (APP-BP1) binds to the carboxyl terminus of APP. In this study, we explored whether APP-BP1 expression is affected by focal transient cerebral ischemia induced by middle cerebral artery occlusion in Wistar rats. APP-BP1 expression was increased in the dentate gyrus of the hippocampus and in the subventricular zone of rats exposed to focal transient cerebral ischemia. In addition, APP-BP1 immunoreactivity overlapped with antidoublecortin and anti-5-bromo-2-deoxyuridine labeling. Focal transient cerebral ischemia has been reported earlier to induce neurogenesis in adult brains. The upregulation of APP-BP1 expression in neural progenitor cells after focal transient ischemia suggests that this protein contributes to the neurogenesis induced by transient ischemia and reperfusion.

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aDepartments of Pharmacology

bNeurosurgery, Boramae Medical Center, Seoul

cSeoul National University Bundang Hospital, Seoul National University, College of Medicine, Sungnam, GyeongGi

dDepartment of Life Science, Pohang University of Science and Technology, Pohang, GyungBuk, Korea

Correspondence to Professor Hye-Sun Kim, PhD, Department of Pharmacology, College of Medicine, Seoul National University, Seoul, 110-799, South Korea Tel: +82 2 740 8298; fax: +82 2 741 8298; e-mail:

Yuyoung Joo and Sang Hyung Lee equally contributed to this study

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Received November 30, 2010

Accepted January 3, 2011

© 2011 Lippincott Williams & Wilkins, Inc.