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Centrally injected kisspeptin reduces food intake by increasing meal intervals in mice

Stengel, Andreas; Wang, Lixin; Goebel-Stengel, Miriam; Taché, Yvette

doi: 10.1097/WNR.0b013e32834558df
MOTIVATION, EMOTION, FEEDING, DRINKING
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Kisspeptin is distributed not only in brain areas for regulating reproduction but also in nuclei involved in feeding control. Whether kisspeptin alters food intake is unknown in mice. We examined how kisspeptin-10 influences feeding after intracerebroventricular injection in mice using automated monitoring. Kisspeptin-10 (0.3, 1, and 3 μg/mouse) dose-dependently inhibited the feeding response to an overnight fast by 50, 95, and 90% respectively, during the 2–3 h period postinjection. The 1μg/mouse dose reduced the 4-h cumulative food intake by 28% whereas intraperitoneal injection (10 μg/mouse) did not. The decreased 4-h food intake was due to reduced meal frequency (−45%/4 h), whereas meal size and gastric emptying were not altered. These data suggest that kisspeptin may be a negative central regulator of feeding by increasing satiety.

CURE/Digestive Diseases Research Center, Center for Neurobiology of Stress, Department of Medicine, Digestive Diseases Division at the University of California Los Angeles, and VA Greater Los Angeles Health Care System, California, USA

Correspondence to Yvette Taché, PhD, Center for Neurobiology of Stress, CURE Building 115, Room 117, VA GLA Healthcare System, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA Tel: +1 310 312 9275; fax: +1 310 268 4963; e-mail: ytache@mednet.ucla.edu

Received December 28, 2010

Accepted February 2, 2011

© 2011 Lippincott Williams & Wilkins, Inc.