NEUROCHEMISTRYTetrahydrocurcumin confers protection against amyloid β-induced toxicityMishra, Shilpa; Mishra, Mamata; Seth, Pankaj; Sharma, Shiv Kumar Author Information National Brain Research Centre, Manesar, Haryana, India Correspondence to Dr Shiv Kumar Sharma, PhD, National Brain Research Centre, Nainwal Mode, Manesar, Haryana 122050, India Tel: +91 124 2845232; fax: +91 124 2338910; e-mail: [email protected] Present address: Mamata Mishra, Department of Neuroscience, School of Medicine, Temple University, 3500 North Broad Street, 7th Floor, Philadelphia, PA 19140, USA Received September 20, 2010 Accepted October 25, 2010 NeuroReport: January 5, 2011 - Volume 22 - Issue 1 - p 23-27 doi: 10.1097/WNR.0b013e328341e141 Buy Metrics Abstract Amyloid plaques and neurofibrillary tangles are the hallmarks of Alzheimer's disease. Amyloid β, a primary component of the amyloid plaques, is neurotoxic. Considerable attention has been directed toward identifying compounds with neuroprotective properties. Using rat primary hippocampal cultures, we show that tetrahydrocurcumin (THC), a metabolite of curcumin, shows a protective effect against oligomeric amyloid-β-induced toxicity. We further show that THC reduces amyloid-β-induced (i) increase in the level of reactive oxygen species, (ii) decrease in mitochondrial membrane potential, and (iii) caspase activation. In addition, we show that THC protects human neurons from oligomeric amyloid-β-induced toxicity as well. Thus, THC confers protection against amyloid-β-induced toxicity, and the antioxidant activity may contribute to its protective effect. © 2011 Lippincott Williams & Wilkins, Inc.