CHEMICAL, SENSESMaturation of newly born vomeronasal neurons in the adult micede la Rosa-Prieto, Carlosa; Saiz-Sánchez, Daniela; Úbeda-Bañón, Isabela; Mohedano-Moriano, Aliciab; Martínez-Marcos, AlinoaAuthor Information aNeuroplasticity and Neurodegeneration Laboratory, Departamento de Ciencias Médicas, Facultad de Medicina de Ciudad Real, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha, Ciudad Real bLaboratorio de Neuroanatomía Humana, Departamento de Ciencias Médicas, Facultad de Medicina, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha, Albacete, Spain Correspondence to Alino Martinez-Marcos, Departamento de Ciencias Médicas, Facultad de Medicina de ciudad Real, University Castilla-La Mancha, Avda. de Moledores S/N, Ciudad Real 13071, Spain Tel: +34 902 204100; fax: +34 902 204130 e-mail: [email protected] Received September 29, 2010 Accepted October 27, 2010 NeuroReport: January 5th, 2011 - Volume 22 - Issue 1 - p 28-32 doi: 10.1097/WNR.0b013e328341fb66 Buy Metrics Abstract The olfactory and vomeronasal epithelia detect chemical stimuli in most tetrapods. Both epithelia undergo neural replacement during adulthood. In the central regions of vomeronasal epithelium, similar rates of neurogenesis and apoptosis evidence balanced replacement mechanisms. In the margins, the rate of neurogenesis is several times higher as compared with the rate of apoptosis suggesting net addition of neural receptor cells during adulthood. Herein, the fate of these marginal neuroblasts has been investigated in adult mice. Newly born and mature receptor neurons have been labeled. In the margins, more than 60% of new-born cells send axons to the accessory olfactory bulb. These results evidence that new neural elements from the vomeronasal epithelium are added to the accessory olfactory bulb preexisting circuitry. © 2011 Lippincott Williams & Wilkins, Inc.