NEUROENDOCRINOLOGYBOLD signal response to cocaine varies with sexual receptivity in female ratsFebo, Marceloa; Segarra, Annabell C.b; Stolberg, Tara L.a; Ferris, Craig F.aAuthor Information aCenter for Translational NeuroImaging, Northeastern University, Boston, Massachusetts bDepartment of Physiology, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico, USA Correspondence to Marcelo Febo, PhD, Department of Psychology, 125 Nightingale Hall, 360 Huntington Avenue, Northeastern University, Boston, MA 02115-5000, USA Tel: +1 617 373 3078; fax: +1 617 373 8714; e-mail: [email protected] Received September 8, 2010 Accepted October 11, 2010 NeuroReport: January 5th, 2011 - Volume 22 - Issue 1 - p 19-22 doi: 10.1097/WNR.0b013e3283416f81 Buy Metrics Abstract Blood oxygen level dependent MRI was used to test whether cocaine-stimulated mesolimbic activity varied with sexual receptivity. Rats were randomly screened for lordotic responses and were then imaged for their responses to centrally administered cocaine. We observed that female rats expressing no lordosis showed a greater activation of mesolimbic and nigrostriatal structures than lordotic female rats. Our data suggest that the differential sensitivity to cocaine occurs not only as a result of hormonal changes of the estrous cycle, but also in association with changes in sexual receptivity. © 2011 Lippincott Williams & Wilkins, Inc.