CLINICAL NEUROSCIENCE AND NEUROPATHOLOGYIntense dopamine innervation of the subventricular zone in Huntington's diseaseBédard, Catherinea; Wallman, Marie-Joséea; Pourcher, Emmanuelleb; Parent, Andréa; Parent, Martina Author Information aDepartment of Psychiatry and Neuroscience, Faculty of Medicine, Université Laval bQuebec Memory and Skills Disorders Research Center, Clinique Sainte-Anne, Quebec City, Quebec, Canada Correspondence to Martin Parent, PhD, Centre de recherche Université Laval Robert-Giffard, 2601, Canardière, Room F-6500, Quebec City, QC G1J 2G3, Canada Tel: +1 418 663 5747; fax: +1 418 663 8756; e-mail: [email protected] Received August 19, 2010 Accepted August 31, 2010 NeuroReport: December 8, 2010 - Volume 21 - Issue 17 - p 1074-1079 doi: 10.1097/WNR.0b013e32834052a6 Buy Metrics Abstract Dopamine exerts a robust promoting effect on adult neurogenesis. Here, we report the presence of an intense dopamine (tyrosine hydroxylase immunoreactive) zone along the ventricular border of the caudate nucleus in patients with Huntington's disease, but not in age-matched controls. This thin (150–400 μm) paraventricular zone was composed of numerous small and densely packed dopamine axon varicosities and overlapped the deep layers of the subventricular zone. Immunoreactivity in the paraventricular zone was 50% higher than in adjacent striatal areas. This intense dopamine zone concurs with the striking increase of neurogenesis noted in the subventricular zone of Huntington's disease patients and indicates that dopamine might play a crucial role in intrinsic mechanisms designed to compensate for the massive striatal neuronal losses that occur in Huntington's disease. © 2010 Lippincott Williams & Wilkins, Inc.