BEHAVIOURThe Drosophila calcineurin regulator, Sarah, is involved in male courtshipSakai, Takaomi; Aigaki, ToshiroAuthor Information Department of Biological Sciences, Tokyo Metropolitan University, Tokyo, Japan Correspondence to Takaomi Sakai, PhD, Department of Biological Sciences, Tokyo Metropolitan University, Tokyo 192-0397, Japan Tel: +81 42 677 2575; fax: +81 42 677 1099; e-mail: [email protected] Received 20 July 2010 accepted 25 July 2010 NeuroReport: October 27, 2010 - Volume 21 - Issue 15 - p 985-988 doi: 10.1097/WNR.0b013e32833eaade Buy Metrics Abstract The Drosophila Sarah (sra) gene encodes a regulator of the Ca2+/calmodulin-dependent protein phosphatase, calcineurin, and plays an essential role in various biological processes. Here, we describe a novel role of sra in Drosophila male courtship behavior. sra null mutant males have reduced courtship activity. This reduced activity can be rescued by expressing sra in the mushroom bodies (MBs), brain structures important for memory formation and storage in Drosophila. In addition, overexpressing sra in the MBs, and transiently overexpressing sra during adulthood, inhibits male courtship. Our results indicate that a specific amount of sra in the MBs is required for wildtype male courtship activity. © 2010 Lippincott Williams & Wilkins, Inc.