LEARNING AND MEMORYRat hippocampus—prefrontal multiple units and synaptic efficacy in vivoFujiwara, Sei-Etsu; Akema, Tatsuo; Izaki, YoshinoriAuthor Information Department of Physiology, St Marianna University School of Medicine, Kawasaki, Japan Correspondence to Sei-Etsu Fujiwara, Department of Physiology, St. Marianna University School of Medicine, Sugao 2-16-1, Miyamae-ku, Kawasaki 216-8511, Japan Tel/fax: +81 44 977 0172; e-mail: [email protected] Received 16 June 2010 accepted 10 August 2010 NeuroReport: October 27, 2010 - Volume 21 - Issue 15 - p 1003-1007 doi: 10.1097/WNR.0b013e32833f4788 Buy Metrics Abstract We recorded multiple unit activities of the CA1 region of the intermediate hippocampus and prelimbic area of the prefrontal cortex, and evoked responses in the prefrontal cortex by hippocampal stimulation in urethane-anesthetized rats. The multiple unit activities between these regions showed significant peaks of cross-correlograms, which indicated that firing initiated mainly from either the hippocampus (type HP) or the prefrontal cortex (type PH). In type HP, the slopes of evoked responses showed a significant inverse correlation with peak heights of cross-correlograms and number of bursts of multiple unit activities. These results suggest that multiple unit activity-based cross-correlograms (a measurement to test functional connectivity) are influenced by both evoked response (synaptic connectivity) and effects of local circuits. © 2010 Lippincott Williams & Wilkins, Inc.